Mitochondrial transfer: Implications for assisted reproductive technologies
نویسندگان
چکیده
The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we provide a detailed overview of mitochondrial transfer techniques - both established and recent - including pronuclear, spindle, ooplasmic and blastomere transfer. Reasons as to why some techniques are more suitable for the prevention of mitochondrial DNA disease than others, as well as the advantages and disadvantages of each methodology, are discussed. The possible clinical introduction of these techniques has raised concerns about the adverse effects they may have on resultant embryos and offspring. Success rates of each technique, embryo viability and developmental consequences post mitochondrial transfer are addressed through analysis of evidence obtained from both animal and human studies. Counterarguments against potential mitochondrial-nuclear genome incompatibility are also provided. Additional clinical applications of mitochondrial transfer techniques are discussed. These include the rescue or enhancement of fertility in women of advanced maternal age or those suffering from diabetes. An alternative to using mitochondrial DNA transfer for germ line therapies is the therapeutic use of somatic cell nuclear transfer for the generation of personalised stem cells. Although ethically challenging, this method could offer patients already suffering from mitochondrial DNA diseases a novel treatment option.
منابع مشابه
Remifentanil versus Fentanyl for Assisted Reproductive Technologies :Effect on Hemodynamic Recovery from Anesthesia and Outcome of ART Cycles
متن کامل
O-9: The Central Role of Mitochondrial Function in Quality of Human Oocyte
Background: Mitochondria are the most aboudent and small essential organelles found in eukaryotic cells. These are semiautonomous organelles for the production of cellular ATP that through its various biochemical pathways. The primary pathway for ATP production is OXPHOS via the electron transfer chain (ETC) which is encoded by nuclear DNA and mtdna genomes. Mitochondria consist of double stran...
متن کاملApplication of Assisted Reproductive Technologies (ART) to Clinical Practice
In the past decade, assisted reproductive technologies (ART) such as oocyte transfer, intracytoplasmic sperm injection (ICSI), and nuclear transfer (cloning) have become effective enough for clinical use. ART such as oocyte transfer and ICSI allow production of foals from mares that cannot provide an embryo by standard embryo-transfer procedures. For the equine practitioner, application of ART ...
متن کاملThe status of assisted reproductive technology in Korea in 2012
OBJECTIVE This study was designed to report the status of assisted reproductive technology (ART) therapy in South Korea between January 1, 2012 and December 31, 2012. METHODS A localized online survey, originally developed by the International Committee Monitoring Assisted Reproductive Technologies, was first launched and provided to all available ART centers via email in 2015. Fresh embryo t...
متن کاملCurrent status of assisted reproductive technology in Korea, 2010
OBJECTIVE Great advances have been made in the field of assisted reproductive technology (ART) since the first in vitro fertilization (IVF) baby was born in Korea. This study was designed to report on the current status of ART therapy in South Korea between January 1 and December 31 of 2010. METHODS A revised survey, originally developed by the International Committee Monitoring Assisted Repr...
متن کامل